CLINICAL NEUROSCIENCE AND NEUROPATHOLOGYEpileptic hypersynchrony revisitedMargineanu, Doru GeorgAuthor Information Department of Neurosciences, Faculty of Medicine and Pharmacy, University of Mons, Mons, Belgium Correspondence to Dr Doru Georg Margineanu, Rue Basse 84/9, 1180 Brussels, Belgium Tel: +32 2 375 35 27; fax: +32 6 537 35 73; e-mail: [email protected] Received 23 July 2010 accepted 27 July 2010 NeuroReport: October 27, 2010 - Volume 21 - Issue 15 - p 963-967 doi: 10.1097/WNR.0b013e32833ed111 Buy Metrics Abstract Synchronization of neuronal responses, which allows coordination of distributed activity patterns, is instrumental in brain functioning, as altered neuronal synchronization is involved in a variety of brain pathologies. Epileptic hypersynchrony chiefly relies on brain wiring, which, in a broader sense, means including astrocytic release of gliotransmitters and electrotonic coupling through gap junctions, beyond classical synaptic connections. Epileptic hypersynchrony also relies on electrical field effects and ion concentration changes in the extracellular space, and it relates to intracellular mechanisms underlying neuronal hyperexcitability. The current lack of a specific impact of hypersynchrony on antiepileptic drug development might be next surpassed, as hypersynchrony seems to be a worthy and approachable, though challenging target of antiepileptic pharmacology. © 2010 Lippincott Williams & Wilkins, Inc.