BEHAVIORAL, INTEGRATIVE AND CLINICAL NEUROSCIENCECentrally administered nesfatin-1 inhibits feeding behaviour and gastroduodenal motility in miceAtsuchi, Kaoria; Asakawa, Akihiroa; Ushikai, Miharua; Ataka, Kojib; Tsai, Mingluna; Koyama, Kenichiroa; Sato, Yukic; Kato, Ikuoc; Fujimiya, Minekob; Inui, AkioaAuthor Information aDepartment of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima bDepartment of Anatomy, Sapporo Medical University Faculty of Medicine, Sapporo cDepartment of Bioorganic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan Correspondence to Dr Akihiro Asakawa, Department of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan Tel: +81 99 275 5751; fax: +81 99 275 5749; e-mail: [email protected] Received 1 July 2010 accepted 16 August 2010 NeuroReport: October 27, 2010 - Volume 21 - Issue 15 - p 1008-1011 doi: 10.1097/WNR.0b013e32833f7b96 Buy Metrics Abstract Nesfatin-1 was recently identified as a peptide with anorexigenic effects that is localized in the hypothalamus and adipocytes. Not much is known about the effect of nesfatin-1 on gut motility. Food intake was measured after intracerebroventricular administration of nesfatin-1 in food-deprived mice. Antral and duodenal motility was assessed by using a manometric method in conscious fed mice. We found that centrally administered nesfatin-1 decreased food intake and inhibited gastroduodenal motility in mice. These results suggest that nesfatin-1 influences gut motility and feeding behaviour. © 2010 Lippincott Williams & Wilkins, Inc.