CLINICAL NEUROSCIENCE AND NEUROPATHOLOGYAbnormal regional homogeneity of drug-naı¨ve obsessive-compulsive patientsYang, Taoa; Cheng, Yuqia b d; Li, Haijunc; Jiang, Hongyana; Luo, Chunrongc; Shan, Baocie; Xu, Linb d; Xu, XiufengaAuthor Information aDepartment of Psychiatry, The First Affiliated Hospital of Kunming Medical College bKey Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences, Kunming Institute of Zoology cMagnetic Resonance Imaging Center, The First Hospital of Kunming City, Kunming, Yunnan dGraduate School of Chinese Academy of Sciences eInstitute of High Energy Physics, Chinese Academy of Sciences, Beijing, China Correspondence to Dr Xiufeng Xu, MD, Department of Psychiatry, The first Affiliated Hospital of Kunming Medical College, 295# Xichang Road, Kunming 650032, PR China Tel: +86 871 5324888 2471; fax: +86 871 5362317; e-mail: [email protected] Tao Yang and Yuqi Cheng contributed equally to this article Received 16 May 2010 accepted 27 May 2010 Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (www.neuroreport.com). NeuroReport: August 4, 2010 - Volume 21 - Issue 11 - p 786-790 doi: 10.1097/WNR.0b013e32833cadf0 Buy SDC Metrics Abstract To explore the possible abnormal resting-state activity in patients with obsessive-compulsive disorder (OCD), the regional homogeneity (ReHo) of 22 pairs of patients and well-matched healthy controls was calculated. Compared with controls, the patients showed higher ReHo in the left anterior cingulate cortex, but lower ReHo in the left inferior temporal gyrus. These findings supported the abnormal resting-state brain activity in drug-naïve OCD patients. No significant correlations between ReHo value and four clinical characteristics were found, suggesting that abnormal ReHo might be trait-related in OCD. © 2010 Lippincott Williams & Wilkins, Inc.