COGNITIVE NEUROSCIENCE AND NEUROPSYCHOLOGYSpatial and temporal aspects of navigation in two neurological patientsvan der Ham, Ineke J.M.a; van Zandvoort, Martine J.E.a b; Meilinger, Tobiasc; Bosch, Sander E.a; Kant, Neeltjea; Postma, Alberta bAuthor Information aExperimental Psychology, Helmholtz Institute, Utrecht University bDepartment of Neurology, University Medical Centre Utrecht, Utrecht, The Netherlands cMax Planck Institute for Biological Cybernetics, Tübingen, Germany Correspondence to Ineke J.M. van der Ham, MSc, Heidelberglaan 2, 3584 CS Utrecht, The Netherlands Tel: +31 30 253 2655; fax: +31 30 253 4511; e-mail: [email protected] Received 6 April 2010 accepted 13 April 2010 NeuroReport: July 14, 2010 - Volume 21 - Issue 10 - p 685-689 doi: 10.1097/WNR.0b013e32833aea78 Buy Metrics Abstract We present two cases (A.C. and W.J.) with navigation problems resulting from parieto-occipital right hemisphere damage. For both the cases, performance on the neuropsychological tests did not indicate specific impairments in spatial processing, despite severe subjective complaints of spatial disorientation. Various aspects of navigation were tested in a new virtual reality task, the Virtual Tübingen task. A double dissociation between spatial and temporal deficits was found; A.C. was impaired in route ordering, a temporal test, whereas W.J. was impaired in scene recognition and route continuation, which are spatial in nature. These findings offer important insights in the functional and neural architecture of navigation. © 2010 Lippincott Williams & Wilkins, Inc.