SLEEPNeuropeptide S mitigates spatial memory impairment induced by rapid eye movement sleep deprivation in ratsZhao, Zhengqing; Huang, Liuqing; Wu, Huijuan; Li, Yanpeng; Zhang, Lin; Yin, You; Xiang, Zhenghua; Zhao, ZhongxinAuthor Information Department of Neurology, Institute of Neuroscience and MOE Key Laboratory of Molecular Neurobiology, Neuroscience Research Center of Changzheng Hospital, Second Military Medical University, Shanghai, PR China Correspondence to Dr Zhongxin Zhao, Department of Neurology, Neuroscience Research Center of Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, PR China Tel/fax: +86 21 8188 5451; e-mail: firstname.lastname@example.org; email@example.com Received 13 February 2010 accepted 11 March 2010 NeuroReport: June 23rd, 2010 - Volume 21 - Issue 9 - p 623-628 doi: 10.1097/WNR.0b013e328339b5f9 Buy Metrics Abstract Rapid eye movement (REM) sleep deprivation causes learning and memory deficits. Neuropeptide S, a newly discovered neuropeptide, has been shown to regulate arousal, anxiety, and may enhance long-term memory formation and spatial memory. However, it is unknown whether neuropeptide S could improve the REM sleep deprivation-induced memory impairment. Here, we report that 72-h REM sleep deprivation in rats resulted in spatial memory impairment and reduced phosphorylation level of cAMP-response element binding protein in the hippocampus, both of which were reversed by central administration of neuropeptide S. The results suggest that neuropeptide S mitigates spatial memory impairment in rats induced by 72-h REM sleep deprivation, possibly through activating cAMP-response element binding protein phosphorylation in the hippocampus. © 2010 Lippincott Williams & Wilkins, Inc.