COGNITIVE NEUROSCIENCE AND NEUROPSYCHOLOGYThe ‘intrinsic’ system in the human cortex and self-projection: a data driven analysisArzy, Shahara d; Arzouan, Yossib; Adi-Japha, Estherc; Solomon, Sorinb; Blanke, OlafdAuthor Information aDepartment of Neurology, Hadassah Hebrew University Hospital bRacah Institute of Physics, Hebrew University, Jerusalem cThe School of Education, Bar-Ilan University, Ramat-Gan, Israel dLaboratory of Cognitive Neuroscience, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland Correspondence to Shahar Arzy, MD, PhD, Department of Neurology, Hadassah Hebrew University Hospital Jerusalem, Israel Tel: +972 2 6777741; fax: +972 2 6437782; e-mail: email@example.com Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (www.neuroreport.com). Received 16 February 2010 accepted 15 March 2010 NeuroReport: June 2nd, 2010 - Volume 21 - Issue 8 - p 569-574 doi: 10.1097/WNR.0b013e328339ebd7 Buy SDC Metrics AbstractIn Brief Information received by the human cortex is supplied by two main sources: extrinsic stimuli delivered by the external environment and intrinsic information regarding the body and self. We reanalyzed electrophysiological data involving the same external stimuli, but manipulating the degree of ‘self-projection’ to locations inside and outside the body border. Electrical neuroimaging and spatial principal component analysis (PCA) showed a bipartition of the cerebral cortex into two main subsystems: occipital and frontal activity was similar across tasks; activity in temporo-parietal and anterior frontal regions was modulated according to the manipulation of self-projection in a given task. These data suggest that the first system relates to external stimulus processing (‘extrinsic’) and the latter one relates to processing of the ‘internal milieu’ of body and self (‘intrinsic’). Supplemental Digital Content is available in the text © 2010 Lippincott Williams & Wilkins, Inc.