CLINICAL NEUROSCIENCE AND NEUROPATHOLOGYSystemic transplantation of embryonic stem cells accelerates brain lesion decrease and angiogenesisNagai, Nobuoa; Kawao, Naoyukia; Okada, Kiyotakaa; Okumoto, Katsumib; Teramura, Takeshic; Ueshima, Shigerua d; Umemura, Kazuoe; Matsuo, OsamuaAuthor Information aDepartment of Physiology bCenter for Morphological Analysis in Central Research Facilities cInstitute of Advanced Clinical Medicine, Kinki University School of Medicine dDepartment of Food Science and Nutrition in Kinki University School of Agriculture eDepartment of Pharmacology, Hamamatsu University School of Medicine, Osaka, Japan Correspondence to Dr Osamu Matsuo, MD, PhD, Department of Physiology, Kinki University School of Medicine, Ohnohigashi 377-2, Osakasayama, Osaka 589-8511, Japan Tel: +81 72 2366 0221; fax: +81 72 366 2853; e-mail: email@example.com Received 16 February 2010 accepted 31 March 2010 NeuroReport: June 2nd, 2010 - Volume 21 - Issue 8 - p 575-579 doi: 10.1097/WNR.0b013e32833a7d2c Buy SDC Metrics Abstract As stem cells can regenerate damaged tissue, their therapeutic potential on brain damage has been investigated. In this study, the effects of embryonic stem cell transplantation on brain damage were investigated by using a photochemically induced thrombotic brain damage model. Mice with systemic transplantation of embryonic stem cells expressing enhanced green fluorescence protein on day 1 showed a smaller brain lesion size on day 8 than the control mice. The smaller lesion was accompanied by the increase in the number of microvessels at the border of the damaged area. Inside and around the damaged lesion, no EGFP-positive cells were observed. These findings suggested that embryonic stem cell transplantation reduced the brain lesion through the acceleration of angiogenesis by endogenous endothelial cells. © 2010 Lippincott Williams & Wilkins, Inc.