BEHAVIORAL, INTEGRATIVE AND CLINICAL NEUROSCIENCEHippocampal SH2-containing protein-tyrosine phosphatases are involved in extinction of contextual fearIsosaka, Tomoko; Yuasa, ShigekiAuthor Information Department of Ultrastructural Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan Correspondence to Dr Shigeki Yuasa, MD, PhD, Department of Ultrastructural Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashimachi, Kodaira, Tokyo 187-8502, Japan Tel: +81 42 346 1719; fax: +81 42 346 1749; e-mail: email@example.com Received 2 February 2010 accepted 14 February 2010 NeuroReport: June 2nd, 2010 - Volume 21 - Issue 8 - p 554-558 doi: 10.1097/WNR.0b013e328338ba4f Buy SDC Metrics Abstract Contextual fear memory is attenuated by re-exposure of animals to a context alone without pairing it with an unconditioned stimulus, and this phenomenon is referred to as fear extinction. In this study we demonstrated that stereotaxic injection of an inhibitor of Src homology 2-containing protein-tyrosine phosphatases 1 and 2 (SHP1/2), NSC87877, into the hippocampus significantly suppressed extinction of contextual fear in the mouse. Intra-hippocampal injection of NSC87877, however, had no effect on the initial memory formation in contextual fear conditioning. These findings suggest that SHP1/2 activity in the hippocampus is involved in the control of contextual fear extinction. © 2010 Lippincott Williams & Wilkins, Inc.