CELLULAR, MOLECULAR AND DEVELOPMENTAL NEUROSCIENCEEffects of infrasound on cell proliferation in the dentate gyrus of adult ratsLiu, Juanfanga; Lin, Tiana; Yan, Xiaodongb; Jiang, Wena; Shi, Minga; Ye, Ruidonga; Rao, Zhirenc; Zhao, GangaAuthor Information Departments of aNeurology bOrthopaedics, Xijing Hospital cInstitute of Neuroscience, Fourth Military Medical University, Xi'an, China Correspondence to Dr Gang Zhao, Department of Neurology, Xijing Hospital, Fourth Military Medical University, 127 West Changle Road, Xi'an 710032, PR China Tel: +86 29 84775361; fax: +86 29 82551806; e-mail: email@example.com Juanfang Liu, Tian Lin and Xiaodong Yan have equally contributed to this study Received 12 March 2010 accepted 31 March 2010 NeuroReport: June 2nd, 2010 - Volume 21 - Issue 8 - p 585-589 doi: 10.1097/WNR.0b013e32833a7dc4 Buy SDC Metrics Abstract Adult rats were used to identify the effects of infrasound on neurogenesis in the hippocampal dentate gyrus. After 7 consecutive days' exposure to infrasound of 16 Hz at 130 dB, immunostaining of 5-bromo-2′-deoxyuridine (BrdU) and doublecortin (DCX) was preformed. Compared with those in normal groups, the numbers of BrdU+ and DCX+/BrdU+ cells in the subgranular zone in infrasound groups were significantly decreased at 3, 6, 10 and 14 days and returned to normal at 18 days. The percentage of BrdU+ cells that were co-labeled with DCX showed no significant differences between the infrasound and normal groups. These data suggest that infrasound inhibits the cell proliferation in adult rat dentate gyrus but has no effects on early migration and differentiation of these newborn cells. © 2010 Lippincott Williams & Wilkins, Inc.