REGENERATION AND TRANSPLANTATIONMMP-2 is involved in synaptic remodeling after cochlear lesionFredrich, Michaela; Illing, Robert-BenjaminAuthor Information Neurobiological Research Laboratory, Department of Otorhinolaryngology, University of Freiburg, Freiburg, Germany Correspondence to Dr Robert-Benjamin Illing, PhD, Neurobiological Research Laboratory, Universitäts-HNO-Klinik, Killianstr. 5, D-79106 Freiburg, Germany Tel: +49 761 270 4273; fax: +49 761 270 4075; e-mail: [email protected] Received 12 November 2009 accepted 24 November 2009 NeuroReport: March 31, 2010 - Volume 21 - Issue 5 - p 324-327 doi: 10.1097/WNR.0b013e328335b518 Buy Metrics Abstract Lesion-induced neuroplasticity, including fiber degeneration, axonal growth, and synaptogenesis, involves dynamical changes of the extracellular matrix. We discovered that the matrix metalloprotease-2 (MMP-2), a major actor in extracellular matrix recomposition, is changed in distribution and increased in amount in the ventral cochlear nucleus after unilateral cochlear ablation. There was a remarkable coincidence of MMP-2 accumulation and GAP-43 expression in time and space. We obtained evidence indicating that MMP-2 is delivered to regions of emerging GAP-43 positive synaptic endings by postsynaptic neurons as well as by adjoining astrocytes. These results indicate a major role of MMP-2 in lesion-induced remodeling of central auditory networks and suggest a cooperativity with GAP-43-directed axonal outgrowth and synaptogenesis. © 2010 Lippincott Williams & Wilkins, Inc.