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Adult neurogenesis is unaffected by a functional knock-out of MHC class I in mice

Laguna Goya, Rocioa; Tyers, Pama; Barker, Roger A.a b c

doi: 10.1097/WNR.0b013e3283377463
MOLECULAR NEUROSCIENCE
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The major histocompatibility complex (MHC) class I has a role in the regulation of immune responses and has been implicated recently in neural plasticity and neurogenesis. We therefore sought to investigate in functional MHC class I knockout mice, transporter associated with antigen processing 1 (TAP1) KO, whether there are alterations in adult neurogenesis. We found no significant differences in cell proliferation or neurogenesis in either the dentate gyrus or subventricular zone, in TAP1 KO versus wild-type mice at several different time points. Our results do not support a role for MHC class I in adult neurogenesis, although it may still have a role in the maturation and integration of newborn neurons.

aCambridge Centre for Brain Repair, Forvie Site, Robinson Way

bDepartment of Neurology, Addenbrookes Hospital, Cambridge, UK

cEdith Cowan University, Perth, Australia

Correspondence to Rocio Laguna Goya, Brain Repair Centre, Forvie Site, CB2 2PY, Cambridge, UK

Tel: +44 1223 331186; fax: +44 1223 331174; e-mail: rl342@cam.ac.uk

Received 15 December 2009 accepted 6 January 2010

© 2010 Lippincott Williams & Wilkins, Inc.