The major histocompatibility complex (MHC) class I has a role in the regulation of immune responses and has been implicated recently in neural plasticity and neurogenesis. We therefore sought to investigate in functional MHC class I knockout mice, transporter associated with antigen processing 1 (TAP1) KO, whether there are alterations in adult neurogenesis. We found no significant differences in cell proliferation or neurogenesis in either the dentate gyrus or subventricular zone, in TAP1 KO versus wild-type mice at several different time points. Our results do not support a role for MHC class I in adult neurogenesis, although it may still have a role in the maturation and integration of newborn neurons.
aCambridge Centre for Brain Repair, Forvie Site, Robinson Way
bDepartment of Neurology, Addenbrookes Hospital, Cambridge, UK
cEdith Cowan University, Perth, Australia
Correspondence to Rocio Laguna Goya, Brain Repair Centre, Forvie Site, CB2 2PY, Cambridge, UK
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Received 15 December 2009 accepted 6 January 2010