LEARNING AND MEMORYLate phase of L-LTP elicited in isolated CA1 dendrites cannot be transferred by synaptic captureVillers, Agnès; Godaux, Emile; Ris, LaurenceAuthor Information Laboratory of Neurosciences, University of Mons, Mons, Belgium Correspondence to Professor Emile Godaux, PhD, MD, University of Mons, Laboratory of Neurosciences, Place du Parc, 20, B-7000 Mons, Belgium Tel: +32 65 37 35 70; fax: +32 65 37 35 73; e-mail: firstname.lastname@example.org Received 13 November 2009 accepted 25 November 2009 NeuroReport: February 17th, 2010 - Volume 21 - Issue 3 - p 210-215 doi: 10.1097/WNR.0b013e328335c311 Buy SDC Metrics Abstract In the CA1 region of mouse hippocampal slices, a strong tetanic stimulation triggers a long-lasting long-term potentiation (L-LTP), which requires transcription for the development of its late phase. Nevertheless, we were able to elicit such an L-LTP in CA1 dendrites separated from their somas provided that we restricted our investigations to isolated dendrites where a very robust early LTP was triggered. This particular type of L-LTP, which relied on translation of preexisting messenger RNAs – as it was blocked by anisomycin – could not be captured by another pathway activated only by a weak tetanic stimulation. This suggests that the plasticity-related proteins resulting from translation of messenger RNAs in dendrites cannot pass from the synaptic site where they were synthesized to another one. © 2010 Lippincott Williams & Wilkins, Inc.