AUDITORY AND VESTIBULAR SYSTEMSAuditory development in the absence of hearing in infancyGordon, Karen Anna b; Valero, Jeromea; Jewell, Stephanie F.a; Ahn, Juliaa; Papsin, Blake C.a bAuthor Information aArchie's Cochlear Implant Laboratory, The Hospital for Sick Children, Toronto bThe Department of Otolaryngology, University of Toronto, Ontario, Canada Correspondence to Karen Ann Gordon, PhD, Archie's Cochlear Implant Laboratory, The Hospital for Sick Children, Rm. 6D08, 555 University Avenue, Toronto, ON, M5G 1×8, Canada Tel: +416 813 7259/6683; fax: +416 813 5036; e-mail: firstname.lastname@example.org Received 25 June 2009 accepted 28 July 2009 NeuroReport: February 17th, 2010 - Volume 21 - Issue 3 - p 163-167 doi: 10.1097/WNR.0b013e328331558a Buy SDC Metrics Abstract The auditory brainstem pathways require stimulation to mature, but do they develop in the absence of auditory input? To answer this, peaks of the electrically evoked auditory nerve (wave eN1) and brainstem response (eII, eIII, and eV) were measured in 117 children with early-onset deafness who had received cochlear implants. Data were collected at cochlear implant activation. In the absence of significant input, the interpeak latency eN1–eIII decreased over the first year of life but remained constant thereafter. Chronic cochlear implant stimulation was required to promote significant reduction in eIII–eV interpeak latency. Thus, activity-independent changes occurring in infancy are concentrated in the caudal auditory brainstem and likely involve the auditory nerve. Changes requiring input are most prevalent in rostral brainstem. © 2010 Lippincott Williams & Wilkins, Inc.