SENSORY AND MOTOR SYSTEMSVesicular glutamate transporters localization in the rat lingual papillaeBraud, Adelinea b; Boucher, Yvesa b; Zerari-Mailly, FawziabAuthor Information aFaculté d'odontologie Paris 7 Denis-Diderot AP-HP, 5, rue Garancière bCricm UMRS 975, France Correspondence to Fawzia Zerari-Mailly, PhD, Laboratoire Physiologie de la Manducation, Bat. A, Case 7077, 7, quai saint Bernard 75005 Paris, France Tel: +33 01 44 27 81 23; fax: +33 01 44 27 81 24; e-mail: email@example.com Received 8 September 2009 accepted 11 October 2009 NeuroReport: January 6th, 2010 - Volume 21 - Issue 1 - p 64-67 doi: 10.1097/WNR.0b013e3283341bd0 Buy Metrics Abstract Vesicular glutamate transporters (VGluts) are widely expressed in neurons of the central nervous system, where they fulfil numerous functions during glutamatergic neurotransmission. This study examines their peripheral distribution in papillae of the tongue using immunohistochemical methods. VGlut 1 was detected in basal layers of the nontaste epithelium, and in intragemmal and perigemmal zones in taste papillae. Neither VGlut 2 nor VGlut 3 was detected in the lingual epithelium and taste papillae. These findings show the specific lingual pattern of distribution for VGluts and suggest that only VGlut 1 takes part in glutamatergic regulation of epithelial and taste cells within the tongue in physiological conditions. © 2010 Lippincott Williams & Wilkins, Inc.