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Sex differences in the temporal lobe white matter and the corpus callosum: a diffusion tensor tractography study

Choi, Chi-Hoona b; Lee, Jong-Minb; Koo, Bang-Bond e; Park, Jun Sungb; Kim, Dae-Shikd e f; Kwon, Jun Sooc; Kim, In Youngb

doi: 10.1097/WNR.0b013e3283345eb0
BRAIN IMAGING

We assessed sex differences in fractional anisotropy (FA) and mean diffusion (MD) of temporal lobe white matter (TLWMFA, TLWMMD), TLWM asymmetry, and the relationship between TLWM asymmetry and FA and MD of the corpus callosum (CCFA, CCMD) using diffusion tensor tractography. We found sex differences in the MD of both inferior longitudinal fasciculus (ILF); however, it disappeared after statistical adjustments for intracranial volume and CCMD variability. FA of the superior longitudinal fasciculus (SLFFA) and FA and MD of the ILF (ILFFA, ILFMD) showed leftward asymmetry. In females, the asymmetry indices of SLFFA and the MD of the SLF were significantly correlated with CCFA and CCMD, respectively, which may be related to sex differences in the hemispheric specialization for language.

aDepartment of Radiology, National Medical Center

bDepartment of Biomedical Engineering, Hanyang University

cDepartment of Psychiatry, Seoul National University College of Medicine, Korea

dDepartment of Anatomy and Neurobiology, Boston University School of Medicine

eNational Emerging Infectious Disease Laboratories Institute (NEIDL)

fCenter for Biological Imaging, Boston University School of Medicine, Massachusetts, USA

Correspondence to Professor Jong-Min Lee, PhD, Computational NeuroImage Analysis Laboratory, Department of Biomedical Engineering, Hanyang University, Sungdong PO Box 55, Seoul 133-605, Korea

Tel: +82 2 2220 0685/0697; fax: +82 2 2296 5943; e-mail: jmlee@bme.hanyang.ac.kr

Received 28 September 2009 accepted 20 October 2009

© 2010 Lippincott Williams & Wilkins, Inc.