SOMATOSENSORY SYSTEMS, PAINCombining functional magnetic resonance imaging with mouse genomics: new options in pain researchHeindl-Erdmann, Corneliaa; Axmann, Rolandb; Kreitz, Silkea; Zwerina, Jochenb; Penninger, Josefc; Schett, Georgb; Brune, Kaya; Hess, AndreasaAuthor Information aExperimental and Clinical Pharmacology and Toxicology bInternal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany cInstitute of Molecular Biology of the Austrian Academy of Sciences, Vienna, Austria Correspondence to Andreas Hess, Friedrich-Alexander-University Erlangen Nuremberg, Fahrstrasse 17, 91054 Erlangen, Germany Tel: +49 9131 85 22003; fax: +49 9131 85 22774; e-mail: firstname.lastname@example.org Cornelia Heindl-Erdmann and Roland Axmann contributed equally to the study Received 9 June 2009 accepted 24 August 2009 NeuroReport: January 6th, 2010 - Volume 21 - Issue 1 - p 29-33 doi: 10.1097/WNR.0b013e3283324faf Buy SDC Metrics Abstract This functional magnetic imaging study investigated the functional implications of genetic modification and pharmacological intervention on cerebral processing of heat-induced nociception in mice. Comparing dynorphin-overexpressing dream−/− with wild-type mice, smaller activated cortical and limbic brain structure sizes could be observed. Moreover, significantly reduced blood oxygenation level-dependent signal amplitudes were found in pain-related brain structures: sensory input, thalamic regions, sensory cortex, limbic system, basal ganglia, hypothalamus and periaqueductal grey. Administration of the specific κ-opioid-receptor antagonist nor-binaltorphimine to dream−/− mice reversed this reduction to wild-type level in the same brain structures. These results show that blood oxygenation level-dependent functional magnetic imaging in the pain system of (transgenic) mice is feasible. Genetic modifications and pharmacological interventions modify brain responses in a structure-specific manner. © 2010 Lippincott Williams & Wilkins, Inc.