Developmental correlation of diffusion anisotropy with auditory-evoked responseRoberts, Timothy P.L.; Khan, Sarah Y.; Blaskey, Lisa; Dell, John; Levy, Susan E.; Zarnow, Deborah M.; Christopher Edgar, J.NeuroReport: December 9th, 2009 - Volume 20 - Issue 18 - p 1586-1591 doi: 10.1097/WNR.0b013e3283306854 AUDITORY AND VESTIBULAR SYSTEMS Abstract Author InformationAuthors Article MetricsMetrics White matter diffusion anisotropy in the acoustic radiations of the auditory pathway was characterized as a function of development in children and adolescents. Auditory-evoked neuromagnetic fields were also recorded from the same individuals, and the latency of the left and right superior temporal gyrus auditory response of approximately 100 ms was also obtained. White matter diffusion anisotropy increased with age. There was a commensurate shortening of the auditory-evoked response latency with increased age as well as with increased white matter diffusion anisotropy. The significant negative correlation between structural integrity of white matter pathways and electrophysiological function (response timing) of distal cortex supports a biophysical model of developmental changes in white matter myelination, conduction velocity, and cortical response timing. Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA Correspondence to Timothy P.L. Roberts, PhD, Department of Radiology, Children's Hospital of Philadelphia, Wood Bldg, Suite 2115, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA Tel: +1 267 426 0384; fax: +1 215 590 1345; e-mail: firstname.lastname@example.org Received 1 July 2009 accepted 3 July 2009 © 2009 Lippincott Williams & Wilkins, Inc.