SOMATOSENSORY SYSTEMS, PAINOlmesartan medoxomil ameliorates sciatic nerve regeneration in diabetic ratsNakamura, Hiroaki; Domon, Yuki; Inoue, Tatsuya; Arakawa, Naohisa; Yokoyama, TomihisaAuthor Information Biological Research Laboratories II, R&D Division Daiichi-Sankyo Co. Ltd., Tokyo, Japan Correspondence to Hiroaki Nakamura, Biological Research Laboratories II, R&D Division, Daiichi-Sankyo Co. Ltd., 2-58, Hiromachi 1-chome, Shinagawa-ku, Tokyo 140-8710, Japan Tel: +81 3 3492 3131; fax: +81 3 5436 8566; e-mail: [email protected] Received 10 June 2009 accepted 31 August 2009 NeuroReport: October 28, 2009 - Volume 20 - Issue 16 - p 1481-1485 doi: 10.1097/WNR.0b013e32833283e6 Buy Metrics Abstract To evaluate the effect of angiotensin II type1 receptor blocker on nerve regeneration delay in diabetic rats, nerve regeneration was monitored by a pinch test on the crushed sciatic nerves of streptozotocin-induced diabetic rats. Nerve regeneration was significantly delayed in diabetic rats and was partly ameliorated by treatment with olmesartan medoxomil (3 mg/kg/day, orally). In the ipsilateral dorsal root ganglia, the mRNA level of insulin-like growth factor-1 and ciliary neurotrophic factor (CNTF) was downregulated, whereas the mRNA level of neurotrophin-3 and CNTF receptor was upregulated. Olmesartan medoxomil significantly enhanced the CNTF expression. These results showed that angiotensin II type1 receptor blocker treatment is effective on nerve regeneration delay in diabetic animals and may provide an effective therapy for clinical diabetic neuropathy. © 2009 Lippincott Williams & Wilkins, Inc.