MOTIVATION, EMOTION, FEEDING, DRINKINGCannabinoid in the nucleus accumbens enhances the intake of palatable solutionShinohara, Yuheia; Inui, Tadashia; Yamamoto, Takashib; Shimura, TsuyoshiaAuthor Information aDivision of Behavioral Physiology, Department of Behavioral Sciences, Graduate School of Human Sciences, Osaka University bDepartment of Health and Nutrition, Faculty of Health Science, Kio University, Nara, Japan Correspondence to Tsuyoshi Shimura, PhD, Division of Behavioral Physiology, Department of Behavioral Sciences, Graduate School of Human Sciences, Osaka University, 1-2 Yamadaoka, Suita, Osaka 565-0871, Japan Tel: +81 6 6879 8048; fax: +81 6 6879 8050; e-mail: email@example.com Received 20 July 2009 accepted 3 Aug 2009 NeuroReport: October 7th, 2009 - Volume 20 - Issue 15 - p 1382-1385 doi: 10.1097/WNR.0b013e3283318010 Buy SDC Metrics Abstract It has been suggested that the activation of cannabinoid receptors in the nucleus accumbens shell facilitates feeding behavior. However, it remains unclear whether cannabinoid ligands enhance the palatability of food to facilitate feeding. In this study, we examined whether microinjecting an endogenous cannabinoid agonist, anandamide into the nucleus accumbens shell would affect the intake of water, sweet or bitter solutions. Microinjections of anandamide into the nucleus accumbens shell selectively increased the intake of saccharin (sweet) solution, but had no effect on the intake of water nor quinine (bitter) solution. These results suggest that activation of the cannabinoid receptors in the nucleus accumbens shell selectively facilitates the intake of palatable foods and solutions. © 2009 Lippincott Williams & Wilkins, Inc.