SOMATOSENSORY SYSTEMS, PAINElectrophysiological correlates of reduced pain perception after theta-burst stimulationCsifcsak, Gabora c; Nitsche, Michael A.a; Baumgärtner, Ulfb; Paulus, Waltera; Treede, Rolf-Detlefb; Antal, Andreaa Author Information aDepartment of Clinical Neurophysiology, Georg-August University, Göttingen bDivision of Neurophysiology, Centre of Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Ruprecht–Karls University Heidelberg, Mannheim, Germany cDepartment of Psychiatry, University of Szeged, Szeged, Hungary Correspondence to Dr Andrea Antal, Department of Clinical Neurophysiology, Georg-August University of Göttingen, Robert Koch Straße 40, Göttingen 37075, Germany Tel: +49 551 398461; fax: +49 551 398126; e-mail: [email protected] Received 28 March 2009 accepted 25 April 2009 NeuroReport: August 5, 2009 - Volume 20 - Issue 12 - p 1051-1055 doi: 10.1097/WNR.0b013e32832e0c74 Buy Metrics Abstract In an earlier study, we reported the antinociceptive effects of a special repetitive transcranial magnetic stimulation paradigm: continuous theta-burst stimulation (cTBS), when applied to human motor cortex. Here, we investigated whether the reduced subjective pain perception of 10 healthy individuals could be measured by changes in laser-evoked potentials, a reflection of pain related activations in the operculoinsular and midcingulate cortex. To minimize the effect of habituation during repeated laser stimulation, a bioadaptive design was used. However, both pain ratings and laser-evoked potential amplitudes were reduced after real and sham cTBS. When compared with sham stimulation, cTBS resulted in a significantly greater diminution of pain ratings and N2–P2 amplitudes on the hand contralateral to the site of motor cortex stimulation. © 2009 Lippincott Williams & Wilkins, Inc.