NEUROPHARMACOLOGY AND NEUROTOXICOLOGYNeuropeptide Y infusion into the shell region of the rat nucleus accumbens increases extracellular levels of dopamineSørensen, Gunnara; Wegener, Gregersb; Hasselstrøm, Jørgenb; Hansen, Thomas V.O.c; Wörtwein, Gittaa; Fink-Jensen, Andersa; Woldbye, David P.D.a Author Information aLaboratory of Neuropsychiatry, Copenhagen Mental Health Center Rigshospitalet, and Department of Neuroscience and Pharmacology, University of Copenhagen bCentre for Psychiatric Research, Aarhus University Hospital, Risskov cDepartment of Clinical Biochemistry, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark Correspondence to David P.D. Woldbye, PhD, MD, Laboratory of Neuropsychiatry, Rigshospitalet University Hospital and Department of Neuroscience and Pharmacology, University of Copenhagen, 9 Blegdamsvej, Copenhagen DK-2100, Denmark Tel: +45 3545 6118; fax: +45 3539 3546; e-mail: [email protected] Received 12 March 2009 accepted 22 April 2009 NeuroReport: July 15, 2009 - Volume 20 - Issue 11 - p 1023-1026 doi: 10.1097/WNR.0b013e32832d4848 Buy Metrics Abstract Increases in extracellular dopamine in the shell region of the nucleus accumbens are centrally involved in mediating reinforcement of addictive drugs. Neuropeptide Y (NPY) and its receptors are present in the nucleus accumbens and have been implicated in addiction mechanisms. This study further explored the potential role of NPY in addiction mechanisms using microdialysis to measure extracellular dopamine in vivo after infusion of NPY directly into the accumbal shell region of adult rats. NPY was found to dose-dependently increase extracellular dopamine levels, indicating that NPY could play an important role in drug reinforcement by modulating accumbal dopamine levels. © 2009 Lippincott Williams & Wilkins, Inc.