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Alterations of white matter diffusion anisotropy in early deafness

Kim, Dae-Jina; Park, Seong-Yonga b; Kim, Jinnaa; Lee, Dong Haa b; Park, Hae-Jeonga b

doi: 10.1097/WNR.0b013e32832e0cdd
BRAIN IMAGING

To explore the effects of white matter in the absence of auditory input in the early deaf, we conducted a tract-based statistical analysis of the diffusion tensor anisotropy and the voxel-based morphometry in the white matter of 13 early deaf and 29 hearing individuals. Deaf individuals showed significant decreases in diffusion anisotropy and in regional volume reductions within the temporal white matter. Decreased anisotropy was also found at the internal capsule, superior longitudinal fasciculus, and the inferior frontal white matter. In contrast, the forceps major of the corpus callosum, where interhemispheric connections between visual cortices exist, showed increased anisotropy. We interpreted these white matter alterations in terms of both disuse-driven atrophy and compensatory plasticity in the early deaf.

aDepartment of Diagnostic Radiology, Nuclear Medicine and Research Institute of Radiological Science

bBK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea

Correspondence to Associate Professor Hae-Jeong Park, PhD, Department of Diagnostic Radiology, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-749, Korea

Tel: +82 2 2228 2363; fax: +82 2 393 3035;

e-mail: parkhj@yuhs.ac; hjpark0@gmail.com

Received 5 May 2009 accepted 10 May 2009

© 2009 Lippincott Williams & Wilkins, Inc.