BRAIN IMAGINGAlterations of white matter diffusion anisotropy in early deafnessKim, Dae-Jina; Park, Seong-Yonga b; Kim, Jinnaa; Lee, Dong Haa b; Park, Hae-Jeonga bAuthor Information aDepartment of Diagnostic Radiology, Nuclear Medicine and Research Institute of Radiological Science bBK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea Correspondence to Associate Professor Hae-Jeong Park, PhD, Department of Diagnostic Radiology, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-749, Korea Tel: +82 2 2228 2363; fax: +82 2 393 3035; e-mail: [email protected]; [email protected] Received 5 May 2009 accepted 10 May 2009 NeuroReport: July 15, 2009 - Volume 20 - Issue 11 - p 1032-1036 doi: 10.1097/WNR.0b013e32832e0cdd Buy Metrics Abstract To explore the effects of white matter in the absence of auditory input in the early deaf, we conducted a tract-based statistical analysis of the diffusion tensor anisotropy and the voxel-based morphometry in the white matter of 13 early deaf and 29 hearing individuals. Deaf individuals showed significant decreases in diffusion anisotropy and in regional volume reductions within the temporal white matter. Decreased anisotropy was also found at the internal capsule, superior longitudinal fasciculus, and the inferior frontal white matter. In contrast, the forceps major of the corpus callosum, where interhemispheric connections between visual cortices exist, showed increased anisotropy. We interpreted these white matter alterations in terms of both disuse-driven atrophy and compensatory plasticity in the early deaf. © 2009 Lippincott Williams & Wilkins, Inc.