NEUROPHYSIOLOGYAdditive effect of cyclooxygenase and nitric oxide synthase blockade on the cerebrocortical microcirculationLacza, Zsombor; Hortobágyi, László; Horváth, Béla; Horváth, Eszter M.; Sándor, Péter; Benyó, Zoltán Author Information Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary Correspondence to Zoltán Benyó, MD, PhD, DSc, Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, PO Box 448, Budapest H-1446, Hungary Tel: +36 20 666 0302; fax: +36 1 334 3162; e-mail: [email protected] Received 15 April 2009 accepted 25 April 2009 NeuroReport: July 15, 2009 - Volume 20 - Issue 11 - p 1027-1031 doi: 10.1097/WNR.0b013e32832d6a93 Buy Metrics Abstract The contribution of vasodilator cyclooxygenase (COX) metabolites to the maintenance of the cerebrocortical blood flow (CBF) has been studied under physiological conditions and in nitric oxide (NO) deficiency. Inhibition of COX decreased resting CBF without changing arterial blood pressure. NO synthase blockade resulted in hypertension and CBF reduction as well as in enhanced cerebral prostacyclin and prostaglandin E2 production. Despite the increased vasodilator prostanoid release in the absence of NO, the CBF-decreasing effect of COX blockade failed to increase. Therefore, the COX pathway seems to play a similar role under physiological and NO-deficient conditions in the maintenance of the resting CBF. © 2009 Lippincott Williams & Wilkins, Inc.