COGNITIVE NEUROSCIENCE AND NEUROPSYCHOLOGYCommon neural mechanisms for explicit timing in the sub-second rangeShih, Lynn Y.L.a e; Kuo, Wen-Juia b e; Yeh, Tzu-Chenc e; Tzeng, Ovid J.L.a b; Hsieh, Jen-Chuena c d e Author Information aInstitute of Neuroscience, School of Life Science bLaboratories for Cognitive Neuroscience cInstitute of Brain Science, School of Medicine dBrain Research Center, National Yang-Ming University eLaboratory of Integrated Brain Research, Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan Correspondence to Jen-Chuen Hsieh, MD, PhD, Professor and Center Director, Institute of Brain Science and Brain Research Center, School of Medicine, National Yang-Ming University, No. 155, Sec. 2, Linong Street, Shih-Pai, Taipei 112, Taiwan Tel: +886 2 28267906; fax: +886 2 28745182; e-mail: [email protected] Received 3 December 2008 accepted 5 December 2008 NeuroReport: July 1, 2009 - Volume 20 - Issue 10 - p 897-901 doi: 10.1097/WNR.0b013e3283270b6e Buy Metrics Abstract Temporal processing is crucial to many cognitive and motor functions. Comparing different aspects of temporal processing is important for a fundamental understanding of its neural mechanisms. In this study, the neural substrates activated during duration discrimination tasks across different sensory modalities, audition and vision, and sensory structures, empty and filled interval, were examined using event-related functional magnetic resonance imaging (MRI). The supplementary motor area and the basal ganglia are suggested as the common neural substrates for temporal processing across sensory modalities and sensory structures for explicit timing in the subsecond range. © 2009 Lippincott Williams & Wilkins, Inc.