Secondary Logo

Institutional members access full text with Ovid®

Analysis of Foxp2 expression in the cerebellum reveals a possible sex difference

Hamson, Dwayne K.; Csupity, Attila S.; Gaspar, John M.; Watson, Neil V.

doi: 10.1097/WNR.0b013e32832a0a44

Deletion of the gene Foxp2 affects ultrasonic vocalizations and induces morphological abnormalities in the Purkinje cell layer of the cerebellum in mice. Castration decreases the production of ultrasonic vocalizations in rats, but the mechanisms of androgenic regulation of ultrasounds are unknown. We explored a possible relationship between Foxp2 expression and androgens in the Purkinje cell layer of wild-type and androgen-insensitive male rats, as well as estrous and nonestrous female rats. Analyses of relative optical densities of Foxp2 immunoreactivity revealed significantly greater immunolabeling in the wild-type and testicular feminization mutation-affected male rats (which did not differ from each other) than in either the estrous or nonestrous female rats (which similarly did not differ from each other). These data suggest a sex difference in Foxp2 expression in the cerebellum.

Behavioral Endocrinology Laboratory, Department of Psychology, Simon Fraser University, British Columbia, Canada

Correspondence to Neil V. Watson, Behavioral Endocrinology Laboratory, Department of Psychology, Simon Fraser University, Burnaby, BC V5A 1S6, Canada

Tel: +778 782 3550; fax: +778 782 3427; e-mail:

The present address of Dwayne K. Hamson is Neuroscience Program and Department of Psychology, Michigan State University, Michigan, USA

1In this paper, we are following the general naming scheme proposed by the Nomenclature Committee for the Forkhead family of genes: Foxp2 in mice, FOXP2 in humans, and FoxP2 in all others species, with genes and RNA denoted by italics [1]. This taxonomy is subject to regular revision: see ‘’ for updates

Received 12 January 2009 accepted 3 February 2009

© 2009 Lippincott Williams & Wilkins, Inc.