BRAIN IMAGINGAbnormal corticostriatal activity during fear perception in bipolar disorderKillgore, William D.S.; Gruber, Staci A.; Yurgelun-Todd, Deborah A.Author Information Cognitive Neuroimaging Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA Correspondence to Dr William D. “Scott” Killgore, PhD, Neuroimaging Center, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA Tel: +1 617 855 3166; fax: +1 617 855 2770; e-mail: [email protected] Received 5 April 2008; accepted 14 July 2008 NeuroReport: October 8, 2008 - Volume 19 - Issue 15 - p 1523-1527 doi: 10.1097/WNR.0b013e328310af58 Buy Metrics Abstract The time course of responses to repeated presentations of affective stimuli is well characterized in healthy individuals but remains to be characterized in patients with bipolar disorder. Using functional magnetic resonance imaging, we compared early-stage and late-stage brain activation during a two-block fearful face perception task in 14 adult bipolar patients to that of 13 healthy controls. Whereas control participants showed increased orbitofrontal, anterior cingulate, and striatum activity during the late (vs. early) stage of the task, bipolar patients failed to show normal task-related activity in these regions. Results suggest that bipolar disorder may involve corticostriatal dysfunction. © 2008 Lippincott Williams & Wilkins, Inc.