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Resting brain metabolic correlates of neuroticism and extraversion in young men

Kim, Sang Heea b; Hwang, Ji Heeb; Park, Hyun Soob; Kim, Sang Euna b

doi: 10.1097/WNR.0b013e328300080f
COGNITIVE NEUROSCIENCE AND NEUROPATHOLOGY

Neuroticism and extraversion are two core dimensions of personality and are considered to be associated with emotional disorders. We investigated resting state brain metabolic correlates of neuroticism and extraversion using a positron emission tomography. Twenty healthy young men completed an 18F-flurodeoxyglucose-PET scan at rest and the Korean version of the revised Eysenck Personality Questionnaire. Neuroticism was negatively correlated with regional glucose metabolism in prefrontal regions including the medial prefrontal cortex. Extraversion was positively correlated with metabolism in the right putamen. These results suggest close associations between resting state brain activity in the prefrontal and striatal regions and specific personality traits and thus contribute to the understanding of the neurobiological bases of predisposition to psychiatric disorders.

aResearch Division of Human Life Sciences, Seoul National University

bDepartment of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Korea

Correspondence to Sang Eun Kim, MD, PhD, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam 463-707, South Korea

Tel: +82 31 787 7671; fax: +82 31 787 4018; e-mail: kse@snu.ac.kr

Received 12 February 2008; accepted 7 March 2008

© 2008 Lippincott Williams & Wilkins, Inc.