BEHAVIORAL, INTEGRATIVE AND CLINICAL NEUROSCIENCEResidual functional connectivity in the split-brain revealed with resting-state functional MRIUddin, Lucina Q.a; Mooshagian, Ericb; Zaidel, Eranb c; Scheres, Anoukd; Margulies, Daniel S.a; Kelly, A.M. Clarea; Shehzad, Zarrara; Adelstein, Jonathan S.a; Castellanos, F. Xaviera; Biswal, Bharat B.e; Milham, Michael P.a Author Information aThe Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, New York University Child Study Center, New York, NY bDepartment of Psychology cBrain Research Institute, University of California Los Angeles, Los Angeles, California dDepartment of Psychology, University of Arizona, Tucson, Arizona eDepartment of Radiology, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA Correspondence to Dr Lucina Q. Uddin, PhD or Michael P. Milham, MD, PhD, New York University Child Study Center, 215 Lexington Avenue, 14th Floor, New York, NY 10016, USA Tel: +1 212 263 4673; fax: +1 212 263 4675; e-mail: [email protected] or [email protected] Received 31 January 2008; accepted 4 February 2008 NeuroReport: May 7, 2008 - Volume 19 - Issue 7 - p 703-709 doi: 10.1097/WNR.0b013e3282fb8203 Buy Metrics Abstract Split-brain patients present a unique opportunity to address controversies regarding subcortical contributions to interhemispheric coordination. We characterized residual functional connectivity in a complete commissurotomy patient by examining patterns of low-frequency BOLD functional MRI signal. Using independent components analysis and region-of-interest-based functional connectivity analyses, we demonstrate bilateral resting state networks in a patient lacking all major cerebral commissures. Compared with a control group, the patient's interhemispheric correlation scores fell within the normal range for two out of three regions examined. Thus, we provide evidence for bilateral resting state networks in a patient with complete commissurotomy. Such continued interhemispheric interaction suggests that, at least in part, cortical networks in the brain can be coordinated by subcortical mechanisms. © 2008 Lippincott Williams & Wilkins, Inc.