Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

Quantification of thalamocortical tracts in schizophrenia on probabilistic maps

Kim, Dae-Jina d; Kim, Jae-Jina b c; Park, Jin Youngb; Lee, Soo Yeole; Kim, Joongilc; Kim, In Youngd; Kim, Sun I.d; Park, Hae-Jeonga b c

doi: 10.1097/WNR.0b013e3282f56634

Diffusion properties of the thalamocortical pathways were compared between 30 schizophrenic patients and 22 healthy age-matched and sex-matched volunteers. T1-weighted and diffusion tensor images were used for cortical parcellation and probabilistic tractography to generate population-based thalamocortical pathway maps. The weighted fractional anisotropy and the longitudinal and transversal diffusivity of each pathway were calculated for individual participants. Patients with schizophrenia demonstrated decreased anisotropy and increased longitudinal and transversal diffusivity within the pathways from the mediodorsal nucleus and the pulvinar to the orbitofrontal and parietal-occipital-temporal lobes. Anisotropy decreases and diffusivity increases were correlated with positive and negative syndrome scale scores. Alterations in global diffusion properties within the thalamocortical pathways imply the disruption of brain circuitry in schizophrenic patients.

aDepartment of Radiology and Nuclear Medicine and Research Institute of Radiological Science

bDepartment of Psychiatry and Institute of Behavioral Science in Medicine

cBK21 Project for Medical Science, Yonsei University College of Medicine

dDepartment of Biomedical Engineering, Hanyang University, Seoul

eDepartment of Biomedical Engineering, Kyung Hee University, Yongin, Gyeonggi-do, Korea

Correspondence to Professor Hae-Jeong Park, PhD, Department of Radiology and Nuclear Medicine, College of Medicine, Yonsei University, 134 Shinchon-Dong, Seodaemoon-Ku, Seoul 120-749, Korea

Tel: +82 2 2228-2363; fax: +82 2 393 3035; e-mail:

Received 26 November 2007; accepted 11 December 2007

© 2008 Lippincott Williams & Wilkins, Inc.