BRAIN IMAGINGQuantification of thalamocortical tracts in schizophrenia on probabilistic mapsKim, Dae-Jina d; Kim, Jae-Jina b c; Park, Jin Youngb; Lee, Soo Yeole; Kim, Joongilc; Kim, In Youngd; Kim, Sun I.d; Park, Hae-Jeonga b cAuthor Information aDepartment of Radiology and Nuclear Medicine and Research Institute of Radiological Science bDepartment of Psychiatry and Institute of Behavioral Science in Medicine cBK21 Project for Medical Science, Yonsei University College of Medicine dDepartment of Biomedical Engineering, Hanyang University, Seoul eDepartment of Biomedical Engineering, Kyung Hee University, Yongin, Gyeonggi-do, Korea Correspondence to Professor Hae-Jeong Park, PhD, Department of Radiology and Nuclear Medicine, College of Medicine, Yonsei University, 134 Shinchon-Dong, Seodaemoon-Ku, Seoul 120-749, Korea Tel: +82 2 2228-2363; fax: +82 2 393 3035; e-mail: [email protected] Received 26 November 2007; accepted 11 December 2007 NeuroReport: March 5, 2008 - Volume 19 - Issue 4 - p 399-403 doi: 10.1097/WNR.0b013e3282f56634 Buy Metrics Abstract Diffusion properties of the thalamocortical pathways were compared between 30 schizophrenic patients and 22 healthy age-matched and sex-matched volunteers. T1-weighted and diffusion tensor images were used for cortical parcellation and probabilistic tractography to generate population-based thalamocortical pathway maps. The weighted fractional anisotropy and the longitudinal and transversal diffusivity of each pathway were calculated for individual participants. Patients with schizophrenia demonstrated decreased anisotropy and increased longitudinal and transversal diffusivity within the pathways from the mediodorsal nucleus and the pulvinar to the orbitofrontal and parietal-occipital-temporal lobes. Anisotropy decreases and diffusivity increases were correlated with positive and negative syndrome scale scores. Alterations in global diffusion properties within the thalamocortical pathways imply the disruption of brain circuitry in schizophrenic patients. © 2008 Lippincott Williams & Wilkins, Inc.