COGNITIVE NEUROSCIENCE AND NEUROPSYCHOLOGYPrism adaptation improves voluntary but not automatic orienting in neglectNijboer, Tanja C.W.a; McIntosh, Rob D.b; Nys, Gudrun M.S.c; Dijkerman, H. Chrisa; Milner, A. DaviddAuthor Information aDepartment of Experimental Psychology, Utrecht University, Utrecht, The Netherlands bSchool of Philosophy, Psychology, and Language Sciences, University of Edinburgh, Edinburgh, United Kingdom cLaboratory for Neuropsychology, Department of Internal Medicine, Neurology Section, Ghent University, Belgium dDepartment of Psychology, Durham University, Durham, United Kingdom Correspondence to Tanja C.W. Nijboer, Utrecht University, Department of Experimental Psychology, Helmholtz Institute, Heidelberglaan 2, 3584 CS Utrecht, the Netherlands Tel: +31302533572; fax: +31302534511; e-mail: email@example.com Received 19 November 2007; accepted 24 November 2007 NeuroReport: February 12th, 2008 - Volume 19 - Issue 3 - p 293-298 doi: 10.1097/WNR.0b013e3282f4cb67 Buy Metrics Abstract Prism adaptation has been shown to temporarily ameliorate the symptoms of unilateral neglect. The underlying mechanisms of change are not yet fully understood. In this study, we investigate the influence of this treatment on attentional orienting under conditions of exogenous (peripheral onset) and endogenous (central symbolic) cueing. In one patient with left visual extinction and recovered neglect, and another patient with left visual neglect, visuo-motor adaptation to a rightward prismatic shift of 10° improved leftward orienting of attention following an endogenous but not an exogenous cue; leftward re-orienting of attention was also improved in the endogenous task for the second patient. We suggest that prism adaptation may ameliorate neglect by improving compensatory processes of leftward voluntary orienting, rather than by a fundamental change in attentional bias. © 2008 Lippincott Williams & Wilkins, Inc.