CHEMICAL, SENSESPeak in matrix metaloproteinases-2 levels observed during recovery from olfactory nerve injuryCostanzo, Richard M.; Perrino, Lisa A.Author Information Department of Physiology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA Correspondence to Richard M. Costanzo, PhD, Department of Physiology, PO Box 980551, Virginia Commonwealth University, Richmond, VA 23298-0551, USA Tel: +1 804 828 4774; fax: +1 804 828 7382; e-mail: email@example.com Received 7 November 2007; accepted 2 December 2007 NeuroReport: February 12th, 2008 - Volume 19 - Issue 3 - p 327-331 doi: 10.1097/WNR.0b013e3282f50c7b Buy Metrics Abstract Matrix metalloproteineases are associated with extracellular remodeling that occurs in injury and repair processes in the central nervous system (CNS). We examined the role of MMP-2 in a model of olfactory nerve injury and found that MMP-2 levels increased several hours following injury, peaked at day 7 and then decreased rapidly. We previously reported a rapid increase in MMP-9, within 5 h after nerve injury, corresponding to neuronal degeneration and increased glial activity. In this study, we show that MMP-2 peaks later than MMP-9, at the onset of neuronal regeneration and repair. Using MMP-9 knockout mice, we determined that the MMP-2 increase is independent of MMP-9. Our data suggest that MMP-2 and MMP-9 may play different roles in the injury and repair processes. © 2008 Lippincott Williams & Wilkins, Inc.