COGNITIVE NEUROSCIENCE AND NEUROPSYCHOLOGYEffects of 4-methylcatechol on spatial memory and depressionSun, Miao-Kun; Alkon, Daniel L.Author Information Blânchette Rockefeller Neurosciences Institute, Rockville, Maryland, USA Correspondence to Miao-Kun Sun, Blânchette Rockefeller Neurosciences Institute, 9601 Medical Center Drive, Academic and Research Bldg, Room 319, Rockville, MD 20850 Tel: +1 301 294 7181; fax: +1 301 294 7007; e-mail: email@example.com Received 12 November 2007; accepted 4 December 2007 NeuroReport: February 12th, 2008 - Volume 19 - Issue 3 - p 355-359 doi: 10.1097/WNR.0b013e3282f519c7 Buy Metrics Abstract Emerging evidence suggests that dementia and depression, two clinical symptoms commonly associated, share the disorder of neuroplasticity in their neural/molecular pathology. Maintenance of sufficient neurostructural remodelling/neurotrophic activity may be central to cognition/antidementia and a balanced mood. Here, we show that intra-cerebroventricular (i.c.v.) 4-methylcatechol (4-MC), a stimulator of brain-derived neurotrophic factor (BDNF) expression and an indirect PKC activator significantly enhanced spatial learning and memory in rats and produced an antidepressant effect. Both effects were eliminated by co-administration of function-blocking anti-BDNF antibody. These results further support the hypothesis that memory processing and mood regulation share common mechanisms and thus therapeutic targets. BDNF enhancers may represent one of the new drug strategies in the fighting against depression associated with memory impairments. © 2008 Lippincott Williams & Wilkins, Inc.