SENSORY AND MOTOR SYSTEMSTheta burst stimulation of the motor cortex reduces laser-evoked pain perceptionPoreisz, Csabaa; Csifcsák, Gábora b; Antal, Andreaa; Levold, Maika; Hillers, Ferdinanda; Paulus, WalteraAuthor Information aDepartment of Clinical Neurophysiology, Georg-August University, Göttingen, Germany bDepartment of Psychiatry, University of Szeged, Szeged, Hungary Correspondence to Dr Csaba Poreisz, MD, Department of Clinical Neurophysiology, Georg-August University of Göttingen, Robert Koch Straße 40, 37075 Göttingen, Germany Tel: +49 551 3912310; fax: +49 551 398126; e-mail: firstname.lastname@example.org Received 5 November 2007; accepted 11 November 2007 NeuroReport: January 22nd, 2008 - Volume 19 - Issue 2 - p 193-196 doi: 10.1097/WNR.0b013e3282f45498 Buy Metrics Abstract Repetitive transcranial magnetic stimulation over the primary motor cortex (M1) was recently introduced to modulate pain perception. The aim of this double-blind cross-over study was to investigate the effect of a modified rTMS paradigm, called cTBS on experimentally induced laser-evoked pain applied over the left M1. cTBS inhibits the cortical excitability of the M1 for approximately 1 h. Subjective pain was measured using the verbal analogue scale prior to, immediately after and 30 min post-stimulation. cTBS, and not the sham stimulation resulted in a significant decrease in pain perception on both hands, accentuated on the right hand. Further studies are needed using motor cortex TBS in chronic pain to pave the way towards a therapeutic tool. © 2008 Lippincott Williams & Wilkins, Inc.