BRAIN IMAGINGPresynaptic and postsynaptic nigrostriatal dopaminergic functions in multiple system atrophyHashimoto, Masayaa c; Kawasaki, Keiichia; Suzuki, Masahikoa c; Mitani, Kazukoa d; Murayama, Shigeob; Mishina, Masahiroa e; Oda, Keiichia; Kimura, Yuichia; Ishiwata, Kiichia; Ishii, Kenjia; Inoue, KiyoharucAuthor Information aPositron Medical Center bDepartment of Neuropathology, Tokyo Metropolitan Institute of Gerontology cDepartment of Neurology, Jikei University School of Medicine dDepartment of Neurology, Tokyo Metropolitan Geriatric Hospital, Tokyo eNeurological Institute, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan Correspondence to Kenji Ishii, Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1-1 Naka-cho, Itabashi-ku, Tokyo 173-0022, Japan Tel: +81 3 3964 3241 EX3503; fax: +81 3 3964 2188; e-mail: email@example.com Received 7 September 2007; accepted 30 October 2007 NeuroReport: January 22nd, 2008 - Volume 19 - Issue 2 - p 145-150 doi: 10.1097/WNR.0b013e3282f3e3d8 Buy Metrics Abstract A simultaneous evaluation of presynaptic and postsynaptic dopaminergic positron emission tomography markers, the dopamine transporters and the dopamine D2-like receptors, was performed in eight patients with parkinsonian phenotype of multiple system atrophy. Both presynaptic and postsynaptic markers were revealed to have declined in such a manner that they kept strong positive correlation throughout the striatum of all patients, suggesting that the degeneration process in the striatum may involve the entire structure of the dopaminergic synapse. In two L-3,4,dihydroxyphenyl-alanine-responsive cases, the balance of decline in two markers was relatively shifted to presynaptic dominant side. Correlative positron emission tomography study of presynaptic and postsynaptic dopaminergic function may be useful for the diagnosis of multiple system atrophy and to understand the mechanisms of its temporal L-3,4,dihydroxyphenyl-alanine responsiveness. © 2008 Lippincott Williams & Wilkins, Inc.