DEVELOPMENTAL NEUROSCIENCEImpoverished rearing impairs working memory and metabotropic glutamate receptor 5 expressionGregory, Mary L.a; Szumlinski, Karen K.bAuthor Information aDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina bDepartment of Psychology and the Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, California, USA Correspondence to Mary Lee Gregory, BS, 173 Ashley River Road, Suite 403 Basic Science Building, Medical University of South Carolina, Charleston, SC, 29425, USA Tel: +1843 763 3361; fax: +1843 792 4423; e-mail: email@example.com Received 16 October 2007; accepted 21 November 2007 NeuroReport: January 22nd, 2008 - Volume 19 - Issue 2 - p 239-243 doi: 10.1097/WNR.0b013e3282f4aa15 Buy Metrics Abstract Impoverished rearing conditions deregulate metabotropic glutamate receptor (mGluR) function and expression within the prefrontal cortex, which contributes to poor performance in positively reinforced spatial working memory tasks. This study extended earlier data by demonstrating that impoverished rearing conditions impair spatial working memory even under conditions of negative reinforcement, indicating a generalized deficit in working memory processing. This protracted behavioral effect was associated with reduced total prefrontal cortex levels of the active, dimerized form of mGluR 5, but there was no change in mGluR 1 or mGluR 2/3 dimer expression in any brain region examined. Thus, impoverished rearing conditions produce protracted deficits in spatial working memory, in association with reduced prefrontal mGluR 5 function that may be relevant to the etiology of several neuropsychiatric disorders. © 2008 Lippincott Williams & Wilkins, Inc.