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Behavioral performance modulates spike field coherence in monkey prefrontal cortex

Wu, Weia c; Wheeler, Diek W.b c; Staedtler, Ellen S.c d; Munk, Matthias H.J.c *; Pipa, Gordonb c *

doi: 10.1097/WNR.0b013e3282f49b29
LEARNING AND MEMORY
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To investigate neuronal processing during short-term memory, we analyzed behavior-related modulations of coupling between signals on two spatial scales: first, very local multiunit activity and second, local field potentials. Coupling was assessed by spike field coherence using a new approach to overcome limitations in cases of low firing rates. We demonstrate the reliability of our approach with simulated data. Application to recordings in prefrontal cortex of two monkeys revealed that locking of spikes was differentially modulated with two different frequency bands depending on behavioral performance.

aFrankfurt International Graduate School for Science

bFrankfurt Institute for Advanced Studies, Johann Wolfgang Goethe University

cMax-Planck-Institute for Brain Research, Deutschordenstr. 46

dDepartment of Anesthesiology, Critical Care and Pain Therapy, Johann Wolfgang Goethe University, Frankfurt, Germany

Correspondence to Gordon Pipa, Max-Planck-Institute for Brain Research, Deutschordenstr. 46, Frankfurt am Main, Hessen, Germany 60528

Tel: +49 69 96769289; fax: +49 69 96769 327; e-mail: pipa@mpih-frankfurt.mpg.de

*Matthias H.J. Munk and Gordon Pipa contributed equally (Gordon Pipa: responsible for the data analysis; Matthias H.J. Munk: responsible for the experimental part)

Received 18 October 2007; accepted 19 November 2007

© 2008 Lippincott Williams & Wilkins, Inc.