BRAIN IMAGINGAuditory stimulus repetition effects on cortical hemoglobin oxygenation: a near-infrared spectroscopy investigationWeiss, Anthony P.; Duff, Margaret; Roffman, Joshua L.; Rauch, Scott L.; Strangman, Gary E.Author Information Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts Correspondence to Anthony P. Weiss, MD, MSc, Department of Psychiatry, MGH-East, Building 149, Room 2606, 13th Street, Charlestown, MA 02129, USA Tel: +617 726 0519; fax: +617 726 4078; e-mail: firstname.lastname@example.org Received 23 October 2007; accepted 21 November 2007 NeuroReport: January 22nd, 2008 - Volume 19 - Issue 2 - p 161-165 doi: 10.1097/WNR.0b013e3282f4aa2a Buy SDC Metrics Abstract The cortical response to repeated sensory stimuli plateaus (or declines) as repetition frequencies increase beyond 2–8 Hz. This study examined the underlying changes in cortical oxygenated and deoxygenated hemoglobin associated with this phenomenon using near-infrared spectroscopy. The optical signal was measured from 11 healthy volunteers listening to noise-burst trains presented at 2, 10, and 35 Hz. In a bilateral region consistent with the posterior superior temporal gyrus there was an inverse relationship between deoxyhemoglobin concentration change and stimulus frequency: greatest at 2 Hz, intermediate at 10 Hz, and smallest at 35 Hz. These findings provide preliminary support for a relationship between the perceptual characteristics of auditory stimuli and modulation of cortical oxygenation as measured via an emerging neuromonitoring technique. © 2008 Lippincott Williams & Wilkins, Inc.