BRAIN IMAGINGEmotional responses to music: towards scientific perspectives on music therapySuda, Miyukia; Morimoto, Kanehisaa; Obata, Akikob; Koizumi, Hideakib; Maki, AtsushibAuthor Information aDepartment of Social and Environmental Medicine, Osaka University Graduate School of Medicine, Suita, Osaka bAdvanced Research Laboratory, Hitachi Ltd, Hatoyama, Saitama, Japan Correspondence to Miyuki Suda, Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan Tel: +81 6 6879 3920; fax: +81 6 6879 3923; e-mail: firstname.lastname@example.org Received 10 October 2007; accepted 11 October 2007 NeuroReport: January 8th, 2008 - Volume 19 - Issue 1 - p 75-78 doi: 10.1097/WNR.0b013e3282f3476f Buy Metrics Abstract Neurocognitive research has the potential to identify the relevant effects of music therapy. In this study, we examined the effect of music mode (major vs. minor) on stress reduction using optical topography and an endocrinological stress marker. In salivary cortisol levels, we observed that stressful conditions such as mental fatigue (thinking and creating a response) was reduced more by major mode music than by minor mode music. We suggest that music specifically induces an emotional response similar to a pleasant experience or happiness. Moreover, we demonstrated the typical asymmetrical pattern of stress responses in upper temporal cortex areas, and suggested that happiness/sadness emotional processing might be related to stress reduction by music. © 2008 Lippincott Williams & Wilkins, Inc.