GENERIC AND NERVOUS SYSTEM DISEASEAssociation between SORL1 and Alzheimer's disease in a genome-wide studyMeng, Yana; Lee, Joseph H.c d; Cheng, Rongc d; St George-Hyslop, Petere f; Mayeux, Richardc d; Farrer, Lindsay A.a b Author Information Departments of aMedicine (Genetics Program) bNeurology, Genetics and Genomics, Epidemiology, and Biostatistics, Boston University Schools of Medicine and Public Health, Boston, Massachusetts cThe Taub Institute on Alzheimer's Disease and the Aging Brain and The Gertrude H. Sergievsky Center, College of Physicians and Surgeons dDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA eDepartment of Medicine, Centre for Research in Neurodegenerative Diseases, University of Toronto fToronto Western Hospital Research Institute, Toronto, Ontario, Canada Correspondence to Dr Lindsay A. Farrer, Boston University School of Medicine, Genetics Program L-320, 715 Albany Street, Boston, MA 02118, USA Tel: +1 617 638 5393; e-mail: [email protected] Current affiliation of Yan Meng, Center for Human Genetic Research, Massachusetts General Hospital, Boston; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. Received 1 August 2007; accepted 16 August 2007 NeuroReport: November 19, 2007 - Volume 18 - Issue 17 - p 1761-1764 doi: 10.1097/WNR.0b013e3282f13e7a Buy Metrics Abstract Several studies have reported an association of Alzheimer's disease (AD) with polymorphic markers in SORL1. Data from a recently published genome-wide association study in AD have been made publicly available. We tested the association of AD with SORL1 in this dataset (Translational Genomics Research Institute; TGEN), which included 31 SORL1 single nucleotide polymorphisms (SNPs), eight of which overlapped the original study. Six SNPs, near the 3′ region of SORL1 containing SNPs which were strongly associated with AD in previous studies, showed significant association in the TGEN dataset. These results provide an independent replication of the association between AD and SORL1. © 2007 Lippincott Williams & Wilkins, Inc.