BRAIN IMAGINGBrain-derived neurotrophic factor val66met polymorphism affects prefrontal energy metabolism in bipolar disorderFrey, Benicio N.a f g; Walss-Bass, Consueloc; Stanley, Jeffrey A.d; Nery, Fabiano G.a h; Matsuo, Kojia i; Nicoletti, Mark A.e; Hatch, John P.a b; Bowden, Charles L.a; Escamilla, Michael A.c; Soares, Jair C.eAuthor Information Department of aPsychiatry bOrthodontics cDepartment of Psychiatry, Psychiatric Genetics Research Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas dDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan eCenter of Excellence for Research and Treatment of Bipolar Disorder, Department of Psychiatry, UNC School of Medicine, Chapel Hill, North Carolina, USA fDepartment of Biochemistry, ICBS, Federal University of Rio Grande do Sul gBipolar Disorders Program, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS hDepartment of Psychiatry, Institute of Psychiatry, University of São Paulo School of Medicine, São Paulo, Brazil iDivision of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan Correspondence to Jair C. Soares, Department of Psychiatry, MD, UNC Center of Excellence for Research and Treatment of Bipolar Disorders (CERT-BD), 10616 Neuroscience Hospital CB#7160, UNC School of Medicine, Chapel Hill, North Carolina 27599 7160, USA Tel: +1 919 966 8832; fax: +1 919 843 3950; e-mail: firstname.lastname@example.org This work was presented in part at the annual meeting of the Society of Biological Psychiatry, 17–19 May 2007, San Diego, California, USA Received 31 January 2007; accepted 11 March 2007 NeuroReport: October 8th, 2007 - Volume 18 - Issue 15 - p 1567-1570 doi: 10.1097/WNR.0b013e3282ef7082 Buy Metrics Abstract Brain-derived neurotrophic factor val66met polymorphism has been implicated in the pathophysiology of bipolar disorder. We investigated the neurochemistry of the left dorsolateral prefrontal cortex of bipolar disorder and healthy participants in relation to the brain-derived neurotrophic factor val66met polymorphism using 1H-magnetic resonance spectroscopy. Absolute N-acetyl-aspartate, phosphocreatine+creatine (PCr+Cr), choline-containing compounds, myo-inositol, and glutamate levels were measured. Bipolar disorder met-carriers had lower PCr+Cr levels than bipolar disorder val/val patients, and bipolar disorder val/val patients had higher PCr+Cr levels than val/val healthy controls. These results indicate that bipolar disorder met-carriers have abnormal energy metabolism in the left dorsolateral prefrontal cortex. © 2007 Lippincott Williams & Wilkins, Inc.