BRAIN IMAGINGA functional magnetic resonance imaging study of emotional Stroop in euthymic bipolar disorderLagopoulos, Jima b; Malhi, Gin S.a bAuthor Information aCADE Clinic, Royal North Shore Hospital bAcademic Discipline of Psychological Medicine, Northern Clinical School, The University of Sydney, Sydney, Australia Correspondence to Dr Jim Lagopoulos, Senior Lecturer, Department of Psychiatry, CADE Clinic, Level 5, Building 36, Royal North Shore Hospital, St Leonards, Sydney, New South Wales 2065, Australia Tel: +61 2 99265506; fax: +61 2 96501033; e-mail: email@example.com Received 19 June 2007; accepted 2 July 2007 NeuroReport: October 8th, 2007 - Volume 18 - Issue 15 - p 1583-1587 doi: 10.1097/WNR.0b013e3282efa07a Buy Metrics Abstract Bipolar disorder is regarded as a disorder of mood and initial studies have focused on structural abnormalities in limbic networks, known to subserve mood. More recently, functional imaging studies allude to affect processing deficits, which may involve frontostriatal networks. This study sought to explore disturbances in networks involved in the processing of negative affect in euthymic bipolar patients. We used simultaneous functional magnetic resonance imaging and galvanic skin responsivity to explore disturbances in these networks. When processing negative affect, controls recruited a distributed subcortical-prefrontal network. In contrast, patients could only activate a subcortical network that included the amygdala and hippocampus. This study provides evidence for a disconnection in the transfer of information within frontostriatal networks in bipolar disorder. © 2007 Lippincott Williams & Wilkins, Inc.