LETTER TO THE EDITORThe peripeduncular nucleus: a novel target for deep brain stimulation?Zrinzo, Ludvica b; Zrinzo, Laurence V.c; Hariz, Marwana d Author Information aUnit of Functional Neurosurgery, Institute of Neurology National Hospital for Neurology and Neurosurgery, London bDepartment of Neurosurgery, Essex Centre for Neurosciences, Queen's Hospital, Romford, Essex, UK cDepartment of Anatomy, Genetics and Cellular Biology, University of Malta, Msida, Malta dDepartment of Neurosurgery, University Hospital, Umeå, Sweden Correspondence to Ludvic Zrinzo, MD MSc FRCSEd, Unit of Functional Neurosurgery, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK Tel: +44 0 78 5578 5271; e-mail: [email protected] Received 3 March 2007; accepted 4 May 2007 NeuroReport: August 6, 2007 - Volume 18 - Issue 12 - p 1301-1302 doi: 10.1097/WNR.0b013e3282638603 Buy Metrics Abstract The pedunculopontine nucleus, a promising new target for deep brain stimulation in Parkinson's disease, straddles the pontomesencephalic junction – unfamiliar territory to most functional neurosurgeons. This contribution reviews the anatomy of the pedunculopontine and peripeduncular nuclei. Given the reported findings of Mazzone et al. in NeuroReport, the authors postulate that the peripeduncular nucleus might be of previously unexpected clinical relevance. © 2007 Lippincott Williams & Wilkins, Inc.