BRAIN IMAGINGLateral response dynamics and hemispheric dominance for speech perceptionHunter, Michael D.a; Lee, Kwang-Hyuka; Tandon, Pannaa; Parks, Randolph W.a; Wilkinson, Iain D.b; Woodruff, Peter W.R.a Author Information aSheffield Cognition and Neuroimaging Laboratory, Academic Clinical Psychiatry bAcademic Unit of Radiology, School of Medicine and Biomedical Sciences, University of Sheffield, UK Correspondence to Dr Michael D. Hunter, Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK Tel: +44 114 226 1514; fax: +44 114 226 1522; e-mail: [email protected] Received 20 April 2007; accepted 12 May 2007 NeuroReport: August 6, 2007 - Volume 18 - Issue 12 - p 1295-1299 doi: 10.1097/WNR.0b013e32827420e4 Buy Metrics Abstract In this study, we investigated the mechanism for the left cerebral hemisphere's dominance for speech perception. We utilized the crossover of auditory pathways in the central nervous system to present speech stimuli more directly to the left hemisphere (via the right ear) and right hemisphere (via the left ear). Using functional MRI, we found that estimated duration of neural response in the left auditory cortex increased as more speech information was directly received from the right ear. Conversely, response duration in the right auditory cortex was not modulated when more speech information was directly received from the left ear. These data suggest that selective temporal responding distinguishes the dominant from nondominant hemisphere of the human brain during speech perception. © 2007 Lippincott Williams & Wilkins, Inc.