GLIAL CELLSAssociation study between the transferrin gene and schizophrenia in the Japanese populationMaeno, Nobuhisaa; Takahashi, Nagahidea; Saito, Shinichia; Ji, Xiaofeia; Branko, Aleksica; Ishihara, Ryokoa; Yoshida, Keizoa; Inada, Toshiyab; Iidaka, Tetsuyaa; Ozaki, NorioaAuthor Information aDepartment of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya bDepartment of Psychiatry, Teikyo University School of Medicine, Chiba Medical Center, Chiba, Japan Correspondence to Nobuhisa Maeno, Department of Psychiatry, Nagoya University Graduate School of Medicine, 65 Tsuruma-Cho, Showa-Ku, Nagoya, Aichi 466-8550, Japan Tel: +81 52 744-2282; fax: +81 52 744-2293; e-mail: firstname.lastname@example.org Received 28 October 2006; accepted 14 December 2006 NeuroReport: March 26th, 2007 - Volume 18 - Issue 5 - p 517-520 doi: 10.1097/WNR.0b013e3280586890 Buy Metrics Abstract Several lines of evidence, including diffusion tensor imaging and microarray studies, indicate that abnormalities in myelination play an important role in the pathophysiology of schizophrenia. Of myelin and oligodendrocyte-related genes, a significant decrease in the mRNA levels of transferrin in schizophrenics has been reported by both microarray and quantitative polymerase chain reaction studies. We performed an association analysis of the transferrin gene in a Japanese population of 384 schizophrenic patients and 384 controls. Six single nucleotide polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism and a TaqMan assay. No significant differences in genotype, allele, or haplotype frequencies of the six single nucleotide polymorphisms were observed between schizophrenic patients and controls. The present results suggest that the transferrin gene is not related to the development of schizophrenia in the Japanese population. © 2007 Lippincott Williams & Wilkins, Inc.