NEUROCHEMISTRYZinc transporter 7 is located in the cis-Golgi apparatus of mouse choroid epithelial cellsChi, Zhi-Honga; Wang, Xina; Wang, Zhan-Youa; Gao, Hui-Linga; Dahlstrom, Annicab; Huang, Lipingc Author Information aDepartment of Histology and Embryology, China Medical University, Shenyang, Liaoning, PR China bDepartment of Biomedicine, Sahlgrens Academy, Goteborg University, Goteborg, Sweden cDepartment of Nutrition and Rowe Program in Genetics, USDA/ARS/Western Human Nutrition Research Center, University of California at Davis, Davis, California, USA Correspondence and requests for reprints to Dr Zhan-You Wang, MD, PhD, Department of Histology and Embryology, China Medical University, Shenyang 110001, Liaoning, PR China Tel/fax: +86 24 23256666 5305; e-mail: [email protected] Sponsorship: This work was supported by the Natural Science Foundation of China (NSFC-30370452), Program for New Century Excellent Talents in University (NCET-04-0288), China Postdoctoral Science Foundation (2005037008), and the Swedish Research Council (Medicine) no. 2207 (A.D.). Received 31 July 2006; accepted 9 August 2006 NeuroReport: November 27, 2006 - Volume 17 - Issue 17 - p 1807-1811 doi: 10.1097/01.wnr.0000239968.06438.c5 Buy Metrics Abstract The cellular localization of zinc transporter 7 protein in the mouse choroid plexus was examined in this study. Zinc transporter 7 immunoreactive cells were detected in the third, lateral, and fourth ventricles of CD-1 mouse brain. Distinct zinc transporter 7 immunoreactivity was concentrated in the perinuclear regions of the positive cells. The results from zinc autometallography showed that zinc-positive grains were also predominantly located in the perinuclear areas. Ultrastructural localization showed that zinc transporter 7 immunostaining was predominantly present in the membrane and cisternae of the cis-Golgi networks and some vesicle compartments. The results support the notion that zinc transporter 7 may participate in the transport of the cytoplasmic zinc into the Golgi apparatus, and may be involved in local packaging of zinc-binding proteins in the mouse choroid plexus. © 2006 Lippincott Williams & Wilkins, Inc.