NEUROPHARMACOLOGY AND NEUROTOXICOLOGYEthanol consumption and reward depend on norepinephrine in the prefrontal cortexVentura, Rossellaa c; Carolis, Donatina Deb c; Alcaro, Antoniob c; Puglisi-Allegra, Stefanob cAuthor Information aDepartment of Biomedical Sciences and Technologies, University of L'Aquila, L'Aquila bDepartment of Psicologia, University ‘La Sapienza’ cFondazione Santa Lucia IRCCSS, European Centre for Brain Research (CERC), Rome, Italy Correspondence and requests for reprints to Dr Rossella Ventura, PhD, Dipartimento di Scienze e Tecnologie Biomediche, Università di L'Aquila, via Vetoio (Coppito 2) 67010 Coppito, L'Aquila, Italy Tel: +39 0649917523; fax: +39 0649917712; e-mail: [email protected] Sponsorship: This research has been supported by the Ministero della Ricerca Scientifica e Tecnologica (PRIN 2005), Università ‘La Sapienza’ Ateneo (2004/2005), Ministero della Salute (Progetto Finalizzato RF03.182P). Received 14 June 2006; accepted 1 August 2006 NeuroReport: November 27, 2006 - Volume 17 - Issue 17 - p 1813-1817 doi: 10.1097/01.wnr.0000239964.83566.75 Buy Metrics Abstract We studied the involvement of norepinephrine in the medial prefrontal cortex in the rewarding/reinforcing effects of ethanol. We evaluated the effects of norepinephrine selective depletion in the medial prefrontal cortex of C57/BL6J inbred mice that are commonly used in molecular studies and are highly susceptible to the behavioral effects of ethanol. In mice with prefrontal norepinephrine depletion, ethanol did not induce conditioned place preference, and a clear-cut reduction of ethanol consumption and preference was evident. These results indicate that prefrontal norepinephrine transmission is a critical factor in the rewarding/reinforcing effects of ethanol. © 2006 Lippincott Williams & Wilkins, Inc.