COGNITIVE NEUROSCIENCE AND NEUROPSYCHOLOGYRapid targeting followed by sustained deployment of visual spatial attentionSimpson, Gregory V.a; Dale, Corby L.a; Luks, Tracy L.a; Miller, William L.a d; Ritter, Walterb; Foxe, John J.b cAuthor Information aDynamic Neuroimaging Laboratory, Department of Radiology, University of California, San Francisco, California bCognitive Neurophysiology Laboratory, Nathan S. Kline Institute for Psychiatric Research, Orangeburg cProgram in Cognitive Neuroscience, Department of Psychology, The City College of the City University of New York, New York, USA d(Current affiliation) Santa Lucia Foundation, IRCCS, Rome, Italy Correspondence and requests for reprints to Professor Gregory V. Simpson, PhD, Dynamic Neuroimaging Laboratory, Department of Radiology, Box 0946, University of California San Francisco, San Francisco, CA 94143-0946, USA Tel: +1 415 353 4571; fax: +1 415 353 9421; e-mail: [email protected] Sponsorship: This work was supported by NIH grants: NS27900 (GVS), NS45171 (GVS) and MH064295 (TLL). Received 13 July 2006; accepted 14 July 2006 NeuroReport: October 23, 2006 - Volume 17 - Issue 15 - p 1595-1599 doi: 10.1097/01.wnr.0000236858.78339.52 Buy Metrics Abstract We investigated preparatory attention processes when a spatial discrimination was required at a cued location, by measuring electroencephalography following a central symbolic cue to deploy spatial attention. Electroencephalography activity in response to the cue revealed three cue-related activations: an early-onset positivity following the P1 at posterior scalp sites contralateral to the cued location, followed by cue-related frontal scalp activity and later-onset sustained activity at posterior scalp sites contralateral to the cued location. The early contralateral positivity may reflect rapid targeting of the cued location. Our results also extend the findings of cue-related frontal activity followed by posterior activity contralateral to the cued location, found with nonspatial feature discriminations, to a task requiring a spatial discrimination. © 2006 Lippincott Williams & Wilkins, Inc.