BRAIN IMAGINGLanguage lateralization in magnetoencephalography: two tasks to investigate hemispheric dominanceRessel, Volkera b; Wilke, Markoa; Lidzba, Karena; Preissl, Hubertb c; Krägeloh-Mann, Ingeborga; Lutzenberger, Wernerb Author Information aDepartment of Pediatric Neurology and Developmental Medicine, Children's Hospital bMEG Center, Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Germany cDepartment of Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA Correspondence and requests for reprints to Mr Volker Ressel, MSc, Department of Pediatric Neurology and Developmental Medicine, Children's Hospital, University of Tübingen, Hoppe-Seyler-Str. 1, 72076 Tübingen, Germany Tel: +49 7071 29 81405; fax: +49 7071 29 5473; e-mail: [email protected] Sponsorship: This work was funded by the Graduate Research Training Program on Cognitive Neurobiology, University of Tübingen, and the German Research Council SFB550 (C4). Received 23 May 2006; accepted 25 May 2006 NeuroReport: July 31, 2006 - Volume 17 - Issue 11 - p 1209-1213 doi: 10.1097/01.wnr.0000230506.32726.be Buy Metrics Abstract Hemispheric specialization for language has been the focus of many studies, mainly using functional magnetic resonance imaging. Here, we used magnetoencephalography to investigate hemispheric dominance and time-dependent aspects of cortical language processing. We implemented a verb generation task and a newly designed vowel identification task. Eleven healthy adults were investigated. By using oscillatory magnetoencephalography spectral analysis, significant hemispheric differences were found for both tasks in cerebral language areas. Robust left-lateralization in frontal brain regions was observed with the verb generation task, confirming previous functional magnetic resonance imaging and magnetoencephalography studies. Our new vowel identification task yields significant left-lateralization in posterior language regions, making this silent and child-friendly task a valuable alternative for non-invasive language assessment in difficult populations. © 2006 Lippincott Williams & Wilkins, Inc.