VISION, CENTRALSpatial frequency-specific potentiation of human visual-evoked potentialsMcNair, Nicolas A.a; Clapp, Wes C.a; Hamm, Jeff P.a; Teyler, Tim J.b c; Corballis, Michael C.a; Kirk, Ian J.aAuthor Information aResearch Centre for Cognitive Neuroscience, University of Auckland, Auckland, New Zealand bMedical Education Program, University of Idaho, Moscow, Idaho, USA cDepartment of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, Washington, USA Correspondence and requests for reprints to Mr Nicolas A. McNair, Psychology Department, Human Sciences Building, University of Auckland, Private Bag 92019, Auckland, New Zealand Tel: +6493737599 ext. 88636; fax: +6493737450; e-mail: firstname.lastname@example.org Sponsorship: Grants from NIH (Grant No. R01 MH064508) and the New Zealand Neurological Foundation (Grant No. 0311-SPG) Received 8 February 2006; revised 20 February 2006; accepted 21 February 2006 All procedures were approved by the University of Auckland Human Subjects Ethics Committee. NeuroReport: May 15th, 2006 - Volume 17 - Issue 7 - p 739-741 doi: 10.1097/01.wnr.0000215775.53732.9f Buy Metrics Abstract Recent research has suggested that cortical long-term potentiation can be induced non-invasively in humans by using rapid visual stimulation. The present study extends these findings by investigating the specificity of this long-term potentiation effect to the inducing stimulus. One group of study participants were tetanized using a one cycle-per-degree sine grating, while a second group was tetanized using a five cycles-per-degree sine grating. Using electroencephalography, we found that an increase in the N1b potential was specific to sine gratings of the same frequency as the tetanus. No effect was observed in the N1b for sine gratings of a different spatial frequency. These results suggest that the long-term potentiation effect induced by the sensory tetanus is isolated to a discrete neural population in the visual cortex. © 2006 Lippincott Williams & Wilkins, Inc.