BEHAVIOURAcute behavioural stress facilitates long-term depression in temporoammonic-CA1 pathwayYang, Jianlia *; Han, Huilib c d *; Cui, Minghua; Wang, Lipingb c d; Cao, Junb c d; Li, Lingjianga; Xu, Lina b c dAuthor Information aMental Health Institute of the 2nd Xiangya Hospital, Central South University, Changsha bKey Laboratory of Animal Models and Human Disease Mechanisms cLaboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, Yunnan dGraduate School of The Chinese Academy of Sciences, Beijing, PR China Correspondence and requests for reprints to Professor Lingjiang Li and Professor Lin Xu, Mental Health Institute of the 2nd Xiangya Hospital, Central South University, Changsha 410011, PR China Tel: +86 871 5195402; e-mails: firstname.lastname@example.org, email@example.com Sponsorship: This work was supported by grants from the National Natural Science Foundation of China (30170342 and 30470621 to L.J.L. and 30530250 and 30470549 to L.X. and 30500150 to J.C.), and 973 Program (2006CB500800 to L.X., L.J.L. and J.C.). *These authors contributed equally to this work. Received 18 January 2006; accepted 3 February 2006 NeuroReport: May 15th, 2006 - Volume 17 - Issue 7 - p 753-757 doi: 10.1097/01.wnr.0000209044.66482.c5 Buy SDC Metrics Abstract Behavioural stress facilitates long-term depression in Schaffer collaterals-CA1 pathway, but it is unknown whether it influences long-term depression in temporoammonic fibres-CA1. Here, we report that low-frequency stimulation induced long-term depression and foot shock stress before slice preparation facilitated long-term depression in both pathways of young rat slices. When the field excitatory postsynaptic potentials were recorded by stimulating the two pathways alternately and low-frequency stimulation was given to the two pathways simultaneously, a reliable long-term depression was induced in Schaffer collaterals-CA1 but a reliable long-term potentiation took place in temporoammonic fibres-CA1. Interestingly, foot shock stress now enabled low-frequency stimulation to induce reliable long-term depressions in both pathways. These findings suggested that acute behavioural stress facilitated long-term depressions in both pathways and disrupted the interactions between pathways. © 2006 Lippincott Williams & Wilkins, Inc.